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Biome Protect is a 4-in-1 formula combining a spore-based probiotic, a non-fiber prebiotic, postbiotic tributyrin, and polyphenols, designed to work even if other probiotics haven't.
From $1.56/day on subscription
FORMULATED BY CHRIS KRESSER, M.S.
Biome Protect is a 4-in-1 formula combining a spore-based probiotic, a non-fiber prebiotic, postbiotic tributyrin, and polyphenols, designed to work even if other probiotics haven't.
From $1.56/day on subscription
"I formulated Biome Protect because nothing on the market did all four jobs at once."
— Chris Kresser, M.S. · Functional medicine practitioner · 15 years clinical experience · 1M+ patients reached
"I formulated Biome Protect because nothing on the market did all four jobs at once."
— Chris Kresser, M.S. · Functional medicine practitioner · 15 years clinical experience · 1M+ patients reached
4.5 ·
A 4-in-1 gut formula for less bloating and regular mornings.

Subscribe & save 10%
$52.14 USD
$57.93 USD
$1.74 USD/day
Ships every 4 weeks · skip or cancel anytime
or
90-day money-back guarantee · Free shipping over $85 USD
Serving size 2 vegetarian capsules · 30 servings
Tributyrin (as CoreBiome®)
300 mg
Bacillus coagulans (probiotic)
2 billion CFU
Pomegranate, grape, cranberry, blueberry extracts
50 mg each
FortiPhage™ prebiotic blend
15 mg
“My longtime constipation is GONE. I’m digesting my food better.”
Jill M., 52 · verified buyer
“I’ve tried Seed and Pendulum. Biome Protect is better than anything I’ve ever tried.”
Sarah H., 47 · verified buyer
“After years of not being able to take any probiotic, it’s the only one that’s ever truly helped.”
Stephanie V., 58 · verified buyer
CK
Formulated by Chris Kresser, M.S., after 15 years in clinical practice.

4.5 ·
A 4-in-1 gut formula for less bloating and regular mornings: a spore-based probiotic, a non-fiber prebiotic, a postbiotic and polyphenols, in 2 capsules a day.
Subscribe & save 10%
$52.14 USD
$57.93 USD
$1.74 USD/day
Ships every 4 weeks · skip or cancel anytime
or
90-day money-back guarantee · Free shipping over $85 USD
Serving size 2 vegetarian capsules · 30 servings
Tributyrin (as CoreBiome®)
300 mg
Bacillus coagulans (probiotic)
2 billion CFU
Pomegranate, grape, cranberry, blueberry extracts
50 mg each
FortiPhage™ prebiotic blend
15 mg
“My longtime constipation is GONE. I’m digesting my food better.”
Jill M., 52 · verified buyer
“I’ve tried Seed and Pendulum. Biome Protect is better than anything I’ve ever tried.”
Sarah H., 47 · verified buyer
“After years of not being able to take any probiotic, it’s the only one that’s ever truly helped.”
Stephanie V., 58 · verified buyer
CK
Formulated by Chris Kresser, M.S., after 15 years in clinical practice.
WHAT MAKES IT DIFFERENT
A clinically studied spore-forming probiotic that survives stomach acid and reaches your colon alive — where it does the work.
LactoSpore® · B. coagulans MTCC 5856 · 6B CFU
A non-fiber prebiotic that selectively nourishes good bacteria, without the gas, bloating, or 'die-off' that fiber-based prebiotics cause.
FortiPhage™ · Bacteriophage prebiotic
Tributyrin: a postbiotic short-chain fatty acid that fuels the cells lining your intestines and helps repair the gut barrier from the inside.
CoreBiome® · Clinically studied tributyrin
A targeted polyphenol blend that helps calm gut irritation and supports a healthier microbial balance long-term.
Polyphenol complex · pomegranate, cranberry, green tea
Free Bio-Avail Colostrum with subscription · 90-day guarantee
WHAT MAKES IT DIFFERENT
A clinically studied spore-forming probiotic that survives stomach acid and reaches your colon alive — where it does the work.
LactoSpore® · B. coagulans MTCC 5856 · 6B CFU
A non-fiber prebiotic that selectively nourishes good bacteria, without the gas, bloating, or 'die-off' that fiber-based prebiotics cause.
FortiPhage™ · Bacteriophage prebiotic
Tributyrin: a postbiotic short-chain fatty acid that fuels the cells lining your intestines and helps repair the gut barrier from the inside.
CoreBiome® · Clinically studied tributyrin
A targeted polyphenol blend that helps calm gut irritation and supports a healthier microbial balance long-term.
Polyphenol complex · pomegranate, cranberry, green tea
Free Bio-Avail Colostrum with subscription · 90-day guarantee
WHAT CUSTOMERS REPORT
4.5 / 5 550+ reviews
"My longtime constipation is GONE. I’m digesting my food better. I have more energy. My mood is better."
Jill M.
Verified Buyer
"I’ve tried Seed and Pendulum. Biome Protect is better than anything I’ve ever tried."
Sarah H.
Verified Buyer
"For the first time in years my digestive issues and bloating are gone."
Mary J.
Verified Buyer
"After years of not being able to take any probiotic, I cautiously tried Biome Protect. It’s the only one that’s ever truly helped."
Stephanie V.
Verified Buyer
WHAT CUSTOMERS REPORT
4.5 / 5 550+ reviews
"My longtime constipation is GONE. I’m digesting my food better. I have more energy. My mood is better."
Jill M.
Verified Buyer
"I’ve tried Seed and Pendulum. Biome Protect is better than anything I’ve ever tried."
Sarah H.
Verified Buyer
"For the first time in years my digestive issues and bloating are gone."
Mary J.
Verified Buyer
"After years of not being able to take any probiotic, I cautiously tried Biome Protect. It’s the only one that’s ever truly helped."
Stephanie V.
Verified Buyer
WHY THIS WORKS WHEN OTHERS HAVEN'T
Typical Probiotic
Bome Protect
What it contains
Just probiotic strains
Probiotic + non-fiber prebiotic + postbiotic + polyphenols
Surviving stomach acid
Most strains die before reaching the gut
Spore-forming strain — survives acid, reaches the gut alive
Prebiotic type
Fiber-based (FOS, inulin) — often causes bloating
Non-fiber (FortiPhage™) — feeds good bacteria without the bloat
Postbiotic support
None
Tributyrin to strengthen the gut barrier
Refrigeration
Required for many strains
Shelf-stable — no fridge needed
Formulator
Marketing team
Chris Kresser — 15+ years in functional medicine
From $1.56/day on subscription
WHY THIS WORKS WHEN OTHERS HAVEN'T
TYPICAL PROBIOTIC
BIOME PROTECT
What it contains
Just probiotic strains
Probiotic + non-fiber prebiotic + postbiotic + polyphenols
Surviving stomach acid
Most strains die before reaching the gut
Spore-forming strain — survives acid, reaches the gut alive
Prebiotic type
Fiber-based (FOS, inulin) — often causes bloating
Non-fiber (FortiPhage™) — feeds good bacteria without the bloat
Postbiotic support
None
Tributyrin to strengthen the gut barrier
Refrigeration
Required for many strains
Shelf-stable — no fridge needed
Formulator
Marketing team
Chris Kresser — 15+ years in functional medicine
From $1.56/day on subscription
INSIDE THE FORMULA
PROBIOTIC
Bacillus coagulans MTCC 5856
A heat-stable, spore-forming probiotic strain that survives stomach acid and reaches the colon alive. Backed by 30+ clinical studies for IBS-related bloating, gas, and bowel regularity.
6B CFU
PREBIOTIC
Bacteriophage prebiotic blend
Selectively targets and reduces gut pathogens while making room for beneficial bacteria — without the fiber-related bloating that derails most prebiotics.
15 mg
POSTBIOTIC
Tributyrin (short-chain fatty acid)
A clinically studied form of butyrate that fuels gut barrier cells, strengthens the intestinal lining, and helps reduce gut inflammation.
300 mg
POLYPHENOLS
Pomegranate · cranberry · blueberry · grape
A targeted blend of polyphenols that further nourishes good bacteria and supports microbial diversity over the long term.
500 mg
No fairy dusting · No junk · Third-party tested ·
Certificates of analysis available to download
INSIDE THE FORMULA
PROBIOTIC
Bacillus coagulans MTCC 5856
A heat-stable, spore-forming probiotic strain that survives stomach acid and reaches the colon alive. Backed by 30+ clinical studies for IBS-related bloating, gas, and bowel regularity.
6B CFU
PREBIOTIC
Bacteriophage prebiotic blend
Selectively targets and reduces gut pathogens while making room for beneficial bacteria — without the fiber-related bloating that derails most prebiotics.
15 mg
POSTBIOTIC
Tributyrin (short-chain fatty acid)
A clinically studied form of butyrate that fuels gut barrier cells, strengthens the intestinal lining, and helps reduce gut inflammation.
300 mg
POLYPHENOLS
Pomegranate · cranberry · blueberry · grape
A targeted blend of polyphenols that further nourishes good bacteria and supports microbial diversity over the long term.
500 mg
No fairy dusting · No junk · Third-party tested ·
Certificates of analysis available to download
MEET YOUR FORMULATOR
I'm Chris Kresser. For the past 15 years I've worked with patients struggling with chronic gut issues, many of them after they'd already tried everything else. What I learned is that most probiotics on the market do one thing well, and three things badly.
They contain strains that don't survive stomach acid. They use fiber-based prebiotics that cause bloating in the very people who need help most. They ignore the postbiotics and polyphenols that actually heal the gut barrier.
I formulated Biome Protect to do all four jobs at once, using clinically studied, branded ingredients at the doses shown to work in the research. No proprietary blends. No filler. No compromises.
If you've tried other probiotics and felt let down, I'm not surprised. I built this for you.
— Chris Kresser, M.S. · Functional Medicine Practitioner · Founder, Adapt Naturals
From $1.56/day on subscription
MEET YOUR FORMULATOR
I'm Chris Kresser. For the past 15 years I've worked with patients struggling with chronic gut issues, many of them after they'd already tried everything else. What I learned is that most probiotics on the market do one thing well, and three things badly.
They contain strains that don't survive stomach acid. They use fiber-based prebiotics that cause bloating in the very people who need help most. They ignore the postbiotics and polyphenols that actually heal the gut barrier.
I formulated Biome Protect to do all four jobs at once, using clinically studied, branded ingredients at the doses shown to work in the research. No proprietary blends. No filler. No compromises.
If you've tried other probiotics and felt let down, I'm not surprised. I built this for you.
— Chris Kresser, M.S. · Functional Medicine Practitioner · Founder, Adapt Naturals
From $1.56/day on subscription
WHAT TO EXPECT
Week 1
Some people notice less bloating after meals within the first few days. Others feel a settling-in period. Both are normal.
Weeks 2–3
Bowel movements typically become more regular and complete. Bloating reduces noticeably.
Month 1
Most customers report 'baseline gut feel' improving, with fewer flare-ups, less reactivity to foods.
Month 3+
Gut barrier integrity, energy, mood, and skin often follow. This is where the deeper changes happen.
This is why we recommend subscription — your gut is rebuilding, not getting a quick fix.
WHAT TO EXPECT
Week 1
Some people notice less bloating after meals within the first few days. Others feel a settling-in period. Both are normal.
Weeks 2–3
Bowel movements typically become more regular and complete. Bloating reduces noticeably.
Month 1
Most customers report 'baseline gut feel' improving, with fewer flare-ups, less reactivity to foods.
Month 3+
Gut barrier integrity, energy, mood, and skin often follow. This is where the deeper changes happen.
This is why we recommend subscription — your gut is rebuilding, not getting a quick fix.
REAL CUSTOMERS, REAL STORIES
JM
Jill M., 52
Multiple gut issues after Lyme treatment
"I have a lot of GI issues after years of antibiotic treatment for Lyme — multiple food sensitivities, leaky gut, candida, SIBO, constipation, bloating. In short, Biome Protect has changed my life. My longtime constipation is GONE. I’m digesting my food better. If I could only choose one supplement, this would be it."
Verified buyer · Subscriber since June
SH
Sarah H., 47
Approaching menopause, Hashimoto's
"I have my diet and lifestyle dialed. I’m approaching menopause and have Hashimoto’s so I support my body with probiotics. I’ve tried Seed and Pendulum which were good for a while, but Adapt’s Biome Protect is better than anything I’ve ever tried. I recommend it to all of my clients, friends, and family now."
Verified buyer · Subscriber since July
SV
Stephanie V., 58
12 years with SIBO
"After getting SIBO 12 years ago and not knowing what it was for years, I tried a lot of gut supplements. I especially experimented with probiotics — but they made my condition worse. After years of not being able to take any, I cautiously tried Biome Protect. It’s been the only probiotic I’ve ever taken that truly helps."
Verified buyer · Subscriber since July
From $1.56/day on subscription
REAL CUSTOMERS, REAL STORIES
JM
Jill M., 52
Multiple gut issues after Lyme treatment
"I have a lot of GI issues after years of antibiotic treatment for Lyme — multiple food sensitivities, leaky gut, candida, SIBO, constipation, bloating. In short, Biome Protect has changed my life. My longtime constipation is GONE. I’m digesting my food better. If I could only choose one supplement, this would be it."
Verified buyer · Subscriber since June
SH
Sarah H., 47
Approaching menopause, Hashimoto's
"I have my diet and lifestyle dialed. I’m approaching menopause and have Hashimoto’s so I support my body with probiotics. I’ve tried Seed and Pendulum which were good for a while, but Adapt’s Biome Protect is better than anything I’ve ever tried. I recommend it to all of my clients, friends, and family now."
Verified buyer · Subscriber since July
SV
Stephanie V., 58
12 years with SIBO
"After getting SIBO 12 years ago and not knowing what it was for years, I tried a lot of gut supplements. I especially experimented with probiotics — but they made my condition worse. After years of not being able to take any, I cautiously tried Biome Protect. It’s been the only probiotic I’ve ever taken that truly helps."
Verified buyer · Subscriber since July
From $1.56/day on subscription
Clinicians’ Choice
Healthcare practitioners stake their professional reputation on products that actually work.
Dr. Mir Ali, MD
Verified Clinician
"I strongly recommend Biome Protect for patients seeking support for digestion and bloating. Because Bacillus coagulans can survive stomach acid, it is able to reach the intestines where it can do its job."
Dr. Donald Nicholas, MD
Verified Clinician
"I like this blend for patients interested in a supplement that can influence gut and skin health at the same time. Gut-friendly bacteria are associated with a healthy gut barrier."
Teresa Byrd, CNS
Verified Clinician
"I highly recommend Biome Protect, and I believe it can be well-suited for those who bloat easily. Gut balance depends on how bacteria interact and not just how many grow."
Clinicians’ Choice
Healthcare practitioners stake their professional reputation on products that actually work.
Dr. Mir Ali, MD
Verified Clinician
"I strongly recommend Biome Protect for patients seeking support for digestion and bloating. Because Bacillus coagulans can survive stomach acid, it is able to reach the intestines where it can do its job."
Dr. Donald Nicholas, MD
Verified Clinician
"I like this blend for patients interested in a supplement that can influence gut and skin health at the same time. Gut-friendly bacteria are associated with a healthy gut barrier."
Teresa Byrd, CNS
Verified Clinician
"I highly recommend Biome Protect, and I believe it can be well-suited for those who bloat easily. Gut balance depends on how bacteria interact and not just how many grow."
QUESTIONS
I've tried other probiotics that didn't work. Why would this be different?
Most probiotics fail for one of three reasons: the strains don't survive stomach acid, the prebiotic causes bloating, or there's no postbiotic to actually heal the gut barrier. Biome Protect uses a spore-forming probiotic that survives acid, a non-fiber prebiotic that doesn't bloat, and adds tributyrin and polyphenols for full-spectrum support. That's why it works for people who've tried everything else.
How long until I notice a difference?
Will it cause bloating or 'die-off' symptoms when I start?
Do I need to refrigerate it?
Can I take it with other supplements?
What's your return policy?
Why subscription instead of a one-time purchase?
Is it third-party tested?
QUESTIONS
I've tried other probiotics that didn't work. Why would this be different?
Most probiotics fail for one of three reasons: the strains don't survive stomach acid, the prebiotic causes bloating, or there's no postbiotic to actually heal the gut barrier. Biome Protect uses a spore-forming probiotic that survives acid, a non-fiber prebiotic that doesn't bloat, and adds tributyrin and polyphenols for full-spectrum support. That's why it works for people who've tried everything else.
How long until I notice a difference?
Will it cause bloating or 'die-off' symptoms when I start?
Do I need to refrigerate it?
Can I take it with other supplements?
What's your return policy?
Why subscription instead of a one-time purchase?
Is it third-party tested?
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Adapt Naturals App
2900 NW Clearwater Dr Ste 200
PMB 165
Bend, OR 97703-9412
(702) 850-2599
Terms of Service · Privacy Policy · Return and Refund Policy · Medical Disclaimer · Your Privacy Choices
© Adapt Naturals 2026. All Rights Reserved.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
SHOP
Shop All
Best Sellers
Health Focus
Quiz
COMPANY
Our Story
Blog
Wholesale
Affiliates
Sustainability
MORE
Give $20, Get $20
Account
FAQ
Get Help
Adapt Naturals App
2900 NW Clearwater Dr Ste 200
PMB 165
Bend, OR 97703-9412
(702) 850-2599
Terms of Service · Privacy Policy · Return and Refund Policy · Medical Disclaimer · Your Privacy Choices
© Adapt Naturals 2026. All Rights Reserved.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.